Development of sustainable entrepreneurship and innovation ecosystems (SEI) is key when universities take on the important role as drivers and enablers of sustainable development. Research in ENHANCERIA is carried out through mapping and then connecting actors somehow engaged in SEI at the ENHANCE universities. The work will 1) allow comparisons and identification of SEI examples, 2) enable learning and integration between actors – both horizontally and vertically and 3) generate insights into how European technical universities can show SEI leadership. By embedding sustainability into the entrepreneurial mindset of students and researchers we will contribute to responsible research and innovation at large. Having an entrepreneurial mindset is regarded as a key resource in the movement towards sustainability and for finding solutions for the grand challenges of today and tomorrow. This will be important for all core tasks of universities: education, research and innovation (including service to society).